SREBF2 drives osteoporosis by divergently regulating Hippo/YAP-mediated adipogenesis and BMP/Smad-mediated osteogenesis in bone marrow stromal cells | Synapse
April 10, 2026
SREBF2 drives osteoporosis by divergently regulating Hippo/YAP-mediated adipogenesis and BMP/Smad-mediated osteogenesis in bone marrow stromal cells
Puntos clave
The study aims to explore how SREBF2 influences the balance between fat cell formation and bone cell formation in bone marrow stromal cells.
Examined the role of SREBF2 in bone marrow stromal cells (BMSCs)
Analyzed the effects on Hippo/YAP and BMP/Smad pathways
Investigated adipogenesis and osteogenesis processes
SREBF2 activation increased adipocyte formation via Hippo/YAP pathway
SREBF2 inhibited bone formation through the BMP/Smad pathway
Targeting SREBF2 showed potential as a therapeutic approach for osteoporosis
Resumen
SREBF2 promotes osteoporosis by activating Hippo/YAP to drive adipogenesis while inhibiting BMP/Smad to suppress osteogenesis in BMSCs. Targeting SREBF2 is a promising therapeutic strategy.