Greater time-updated vericiguat exposure was linked to less myocardial fibrosis and reduced rehospitalizations in older adults with worsening HFrEF, especially with higher GDMT-4.
Does higher vericiguat dose exposure reduce myocardial fibrosis burden in older adults with worsening heart failure with reduced ejection fraction?
Older adults with worsening heart failure with reduced ejection fraction
Vericiguat (different dose exposures)
Myocardial fibrosis burdensurrogate
Higher vericiguat exposure is associated with reduced myocardial fibrosis and fewer rehospitalizations in older adults with worsening HFrEF, particularly when combined with quadruple guideline-directed medical therapy.
Tasa de eventos absoluta: 0% vs 0%
Greater time-updated vericiguat exposure was linked to less fibrosis and an exploratory reduction in rehospitalizations, especially with higher GDMT-4.
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Ge et al. (Fri,) reported a other. Greater time-updated vericiguat exposure was linked to less myocardial fibrosis and reduced rehospitalizations in older adults with worsening HFrEF, especially with higher GDMT-4.
synapsesocial.com/papers/69d894526c1944d70ce0541a — DOI: https://doi.org/10.14744/anatoljcardiol.2026.5960
Liyong Ge
Guiyang Medical University
Guoqiu Wang
Guiyang Medical University
Anning Zeng
Qiannan Normal College For Nationalities
Guiyang Medical University
Affiliated Hospital of Guizhou Medical University
Guizhou Provincial People's Hospital
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