What question did this study set out to answer?

The study aims to investigate the effects of pregnenolone-isoxazole hybrids on mitochondrial apoptosis in breast cancer cells.

April 10, 2026RSC Medicinal Chemistry1 citations

A Comprehensive Study of Novel Pregnenolone-Isoxazole Hybrids as Selective Inducers of Mitochondrial Apoptosis in Breast Cancer Cells

VMVictoria MalakhovaN.D. Zelinsky Institute of Organic Chemistry ASAlexander M. ScherbakovRussian Cancer Research Center NN Blokhin DSDiana I. SalnikovaN.D. Zelinsky Institute of Organic Chemistry

Puntos clave

The study aims to investigate the effects of pregnenolone-isoxazole hybrids on mitochondrial apoptosis in breast cancer cells.
Developed novel pregnenolone-isoxazole hybrid compounds
Assessed their impact on apoptosis induction
Examined mitochondrial dysfunction in breast cancer cells
Identified effective inducers of mitochondrial apoptosis
Demonstrated disruption of mitochondrial function in cancer cells
Showed potential for targeting multiple cancer-related pathways

Resumen

Heterocyclic derivatives of steroids have emerged as promising anticancer agents by concurrently targeting multiple pathways, including apoptosis induction, cell cycle arrest, and mitochondrial dysfunction. Here, we report novel pregnenolone-isoxazole hybrids...

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Cite This Study

Malakhova et al. (Thu,) studied this question.

synapsesocial.com/papers/69d895a86c1944d70ce06aba https://doi.org/https://doi.org/10.1039/d6md00076b

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