The CYP2C:TG haplotype was not significantly associated with CYP2C19-mediated omeprazole metabolism in admixed Latin American populations, not supporting its clinical implementation.
Observational
Sí
Is the CYP2C:TG haplotype associated with CYP2C19-mediated omeprazole metabolism in admixed Latin American populations?
Admixed Latin American (Mestizo) populations in Ecuador and Nicaragua
CYP2C:TG haplotype
CYP2C19-mediated omeprazole metabolismsurrogate
The study does not support clinical implementation of CYP2C:TG haplotype testing for predicting CYP2C19 activity in admixed Latin American populations.
In these admixed Latin American populations, the CYP2C:TG haplotype was not significantly associated with CYP2C19-mediated omeprazole metabolism. This finding does not support clinical implementation of CYP2C:TG haplotype testing for predicting CYP2C19 activity and underscores the need for further research on this haplotype and its potential role in CYP2C19 metabolism across diverse populations in the context of pharmacogenetics.
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Carla González de la Cruz
Government of Extremadura
Catalina Altamirano-Tinoco
Juan Antonio Villatoro-García
Latin American and Caribbean Society of Medical Oncology
Pharmacogenomics
American University
Universidad de Extremadura
Universidad San Francisco de Quito
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Cruz et al. (Wed,) conducted a observational in CYP2C19-mediated omeprazole metabolism. CYP2C:TG haplotype was evaluated on CYP2C19-mediated omeprazole metabolism. The CYP2C:TG haplotype was not significantly associated with CYP2C19-mediated omeprazole metabolism in admixed Latin American populations, not supporting its clinical implementation.
synapsesocial.com/papers/69d895d86c1944d70ce06f71 — DOI: https://doi.org/10.1080/14622416.2026.2646516
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