What question did this study set out to answer?

To evaluate the role of cerebrospinal fluid IgG4 levels in diagnosing IgG4-related spinal pachymeningitis.

April 10, 2026

Cerebrospinal Fluid IgG4 as a Key Diagnostic Clue in IgG4‐Related Spinal Pachymeningitis With Normal Serum Levels

To evaluate the role of cerebrospinal fluid IgG4 levels in diagnosing IgG4-related spinal pachymeningitis.
Analyzed cerebrospinal fluid samples from patients with suspected spinal pachymeningitis.
Compared IgG4 levels in cerebrospinal fluid to serum levels.
Identified diagnostic markers for the condition.
Elevated IgG4 levels were found in cerebrospinal fluid despite normal serum levels.
The study highlights cerebrospinal fluid IgG4 as a potential diagnostic marker.
Findings suggest a distinct pathophysiological role for IgG4 in spinal pachymeningitis.

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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