Inflammation and Blood-Brain Barrier in Depression: Interaction ofCLDN5andIL6Gene Variants in Stress-Induced Depression

These findings provide genetic evidence in humans for the interaction among interleukin-6, claudin-5, and recent stress, suggesting that inflammation is involved in the development of depression and that stress-connected brain entry of inflammatory molecules is a key factor in this pathomechanism. These genetic polymorphisms may help to identify people at higher risk for recent stress-induced depression.