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Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme | Synapse

May 17, 2015Open Access

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Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

NKNorbert KrugFraunhofer Institute for Toxicology and Experimental Medicine JHJens M. HohlfeldMedizinische Hochschule Hannover AKAnne‐Marie KirstenGerman Center for Lung Research

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Resumen

Treatment with SB010 significantly attenuated both late and early asthmatic responses after allergen provocation in patients with allergic asthma. Biomarker analysis showed an attenuation of Th2-regulated inflammatory responses. (Funded by Sterna Biologicals and the German Federal Ministry of Education and Research; ClinicalTrials.gov number, NCT01743768.).

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Cite This Study

Krug et al. (Sun,) studied this question.

synapsesocial.com/papers/69d8a951d2f7327e70ae3da7 https://doi.org/https://doi.org/10.1056/nejmoa1411776