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May 27, 2020Open Access

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PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease

SISidikjan IbrahimHubei Cancer Hospital XZXu ZhuQingdao University of Science and Technology XLXuelai LuoTongji Hospital

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Resumen

PIK3R3 was increased in clinical IBD patients with accompanying disruption of ZO-1 expression. Inhibition of PIK3R3 attenuated DSS-induced IBD symptoms in a mouse model. These findings indicated that PIK3R3 could be a therapeutic target for IBD.

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Cite This Study

Ibrahim et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8c2bf2c39562886ae299a https://doi.org/https://doi.org/10.1016/j.intimp.2020.106610

PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease | Synapse

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