Are mitotic activity, grade, size, histologic type, and age prognostic for survival and local recurrence in extremity soft tissue sarcoma?
Objective pathologic features like mean mitotic activity are useful prognostic indicators for survival and can help select patients for future trials and primary therapy in extremity soft tissue sarcoma.
The use of mitotic activity along with grade, size, histologic type, and age at diagnosis is prognostic for survival in extremity soft tissue sarcoma. The use of an objective pathologic feature, such as mean mitotic activity, is also useful in selecting patients for future systemic neoadjuvant or adjuvant trials and primary therapy.
Singer et al. (Tue,) studied this question.