August 15, 2022Open Access

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease

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Resumen

Our study, for the first time, revealed that pTau contributes to neuronal death by inducing necroptosis and inflammation, mediated by activating the RIPK1/RIPK3/MLKL and NF-κB pathways, thereby delineating the hierarchical molecular network of neuronal necroptosis induction in AD.

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Cite This Study

Dong et al. (Mon,) studied this question.

synapsesocial.com/papers/69d91b16d8690e49a783597f https://doi.org/https://doi.org/10.1186/s12974-022-02567-y

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1Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases2013 · 114 citations
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3Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β2000 · 3,264 citations
4Elevated circulating tumor necrosis factor levels in Alzheimer's disease1991 · 511 citations
5The distribution of tau in the mammalian central nervous system.1985 · 1,607 citations

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