Which lipid risk factors are most strongly associated with the development of myocardial infarction in patients ≤ 40 years of age?
Non-HDL cholesterol is the strongest lipid risk predictor for premature myocardial infarction in patients ≤ 40 years, whereas small dense LDL particles do not appear useful for risk prediction in this population.
Non-HDL cholesterol is most strongly associated with premature coronary artery disease and could serve as preferred risk predictor and therapeutic target in this young patient population (≤ 40 years). Besides, VLDL, LDL-C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction. Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors.
Goliasch et al. (Thu,) studied this question.
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