June 8, 2010

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

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Resumen

Müller cell-derived VEGF plays an essential and causative role in retinal inflammation, vascular lesions, and vascular leakage in DR. Therefore, Müller cells are a primary cellular target for proinflammatory signals that mediates retinal inflammation and vascular leakage in DR.

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Cite This Study

Wang et al. (Tue,) studied this question.

synapsesocial.com/papers/69d987ef8988aeabbe6859e0 https://doi.org/https://doi.org/10.2337/db09-1420

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Temporal requirement of RPE‐derived VEGF in the development of choroidal vasculature2010 · 49 citations
2Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.1991 · 487 citations
3Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus2006 · 24 citations
4Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders1994 · 3,789 citations
5Vascular Endothelial Growth Factor Antagonist Modulates Leukocyte Trafficking and Protects Mouse Livers against Ischemia/Reperfusion Injury2006 · 49 citations

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