Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

Puntos clave

• The aim is to explore how cognitive reserve influences the age at which symptoms begin and the rate of cognitive decline in Alzheimer disease.
• Analyzed cognitive reserve values in individuals with dominantly inherited Alzheimer disease.
• Evaluated the association between cognitive reserve and onset of mild cognitive impairment.
• Measured progression using clinical dementia rating scales.
• Higher cognitive reserve is linked to later onset of mild cognitive impairment.
• Individuals with greater cognitive reserve showed slower progression on dementia scales.
• Cognitive reserve appears to offer a protective effect against clinical decline.