June 10, 2003

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

PICO estructurado

Does infliximab improve the clinical condition in patients with moderate-to-severe chronic heart failure?

Población

Patients with moderate-to-severe chronic heart failure

Intervención

Infliximab (short-term TNFalpha antagonism, including high doses of 10 mg/kg)

Comparador

Placebo

Resultado

Clinical condition

Short-term use of infliximab does not benefit and may harm patients with moderate-to-severe heart failure, particularly at high doses.

Resumen

Short-term TNFalpha antagonism with infliximab did not improve and high doses (10 mg/kg) adversely affected the clinical condition of patients with moderate-to-severe chronic heart failure.

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