Inflammatory dysregulation in obesity operates through different mechanisms in men and women, suggesting a need for sex-specific therapeutic strategies.
We identified sex-specific pathways that influence inflammation in obesity. Excessive production of proinflammatory cytokines was observed in men with metabolic syndrome. In contrast, women typically showed reduced levels of the anti-inflammatory adipokine adiponectin. These different mechanisms of inflammatory dysregulation between women and men with obesity argue for sex-specific therapeutic strategies.
Horst et al. (Thu,) studied this question.
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