March 30, 2012Open Access

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

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Resumen

Activating the renal RAAS/TGF-β pathway has an important pathological role in chronic kidney injury caused by IS and PCS. IS and PCS may increase Snail expression and induce EMT-like transition.

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Sun et al. (Fri,) studied this question.

synapsesocial.com/papers/69da1bd00f32475823a3cdec https://doi.org/https://doi.org/10.1371/journal.pone.0034026

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5Human Cytomegalovirus Induces TGF-β1 Activation in Renal Tubular Epithelial Cells after Epithelial-to-Mesenchymal Transition2010 · 62 citations

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