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Incidence and extent of TDP-43 accumulation in aging human brain | Synapse

June 19, 2015Open Access

Incidence and extent of TDP-43 accumulation in aging human brain

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Resumen

In conclusion, TDP-43 immunoreactive DNs may develop as a consequence of aging processes in the human brain. In particular, the uncus of the anterior hippocampus is an area highly susceptible to TDP-43 accumulation over age 65.

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Cite This Study

Uchino et al. (Fri,) studied this question.

synapsesocial.com/papers/69da2549ba6014a02e8361a4 https://doi.org/https://doi.org/10.1186/s40478-015-0215-1

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2006 · 2,792 citations
2The Human Hippocampus2005 · 357 citations
3Atlas of the Human Brain1997 · 1,417 citations
4Neuropathological stageing of Alzheimer-related changes1991 · 16,354 citations
5Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease2008 · 109 citations