Are circulating monocyte-platelet aggregates a more sensitive marker of in vivo platelet activation than platelet surface P-selectin?
Circulating monocyte-platelet aggregates serve as a more sensitive biomarker for in vivo platelet activation compared to platelet surface P-selectin.
As demonstrated by 3 independent means (in vivo tracking of activated platelets in baboons, human coronary intervention, and human AMI), circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin.
Michelson et al. (Tue,) studied this question.