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Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges | Synapse

April 13, 2011Open Access

Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges

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Detailed validation of the preanalytical steps affecting miRNA detection and quantification is critical when considering the use of individual miRNAs as clinical biomarkers. Unless these causes of imprecision are considered and mitigated, only miRNAs that are extremely up- or downregulated will be suitable as clinical biomarkers.

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Cite This Study

McDonald et al. (Wed,) studied this question.

synapsesocial.com/papers/69da691294a959ed41a3c837 https://doi.org/https://doi.org/10.1373/clinchem.2010.157198