August 1, 2023Open Access

Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis

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Resumen

Upregulation of SLC7A11 can be induced by androgen receptor variants to inhibit antiandrogen-induced prostate cancer cell ferroptosis and to drive castration resistance in prostate cancer.

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Sun et al. (Tue,) studied this question.

synapsesocial.com/papers/69da71ee0f778bd2e4684d91 https://doi.org/https://doi.org/10.1158/0008-5472.can-23-0285

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 12011 · 459 citations
2Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death2012 · 18,233 citations
3The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond2011 · 601 citations
4Fatty acid synthase: A metabolic oncogene in prostate cancer?2003 · 293 citations
5BAP1 links metabolic regulation of ferroptosis to tumour suppression2018 · 1,039 citations

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