Nonopioid, Multimodal Analgesia as First‐line Therapy After Otolaryngology Operations: Primer on Nonsteroidal Anti‐inflammatory Drugs (NSAIDs)

The combination of NSAIDs and acetaminophen provides more effective postoperative pain control with greater safety than opioid-based regimens. The AAO-HNS opioid prescribing CPG therefore prioritizes multimodal, nonopioid analgesia as first-line therapy, recommending that opioids be reserved for severe or refractory pain. This state-of-the-art review provides strategies for safely incorporating NSAIDs into acute postoperative pain regimens.