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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme ChemistryRoland K. O. Sigel and Anna Marie PyleView Author Information Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520 Cite this: Chem. Rev. 2007, 107, 1, 97–113Publication Date (Web):December 19, 2006Publication History Received27 February 2006Published online19 December 2006Published inissue 1 January 2007https://doi.org/10.1021/cr0502605Copyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3095Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertscloseSUBJECTS:Catalysis,Genetics,Ions,Metals,Peptides and proteins Get e-Alerts
Sigel et al. (Tue,) studied this question.