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NFE2L1-mediated proteasome function protects from ferroptosis | Synapse

January 6, 2022Open Access

NFE2L1-mediated proteasome function protects from ferroptosis

SKStefan KotschiConsejo Nacional de Investigaciones Científicas y Técnicas AJAnna JungLMU Klinikum NWNienke WillemsenCell and Gene Therapy Catapult

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Resumen

Our data highlight the relevance of the NFE2L1-proteasome pathway in ferroptosis. Manipulation of NFE2L1 activity might enhance ferroptosis-inducing cancer therapies as well as protect from aberrant ferroptosis in neurodegeneration, general metabolism, and beyond.

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Cite This Study

Kotschi et al. (Thu,) studied this question.

synapsesocial.com/papers/69daab2c0f32475823a3d7d3 https://doi.org/https://doi.org/10.1016/j.molmet.2022.101436