Diastereodivergent synthesis of fully disubstituted spiroindoline-3,2′-pyrrolidin-2-ones via tuneable Lewis base/Brønsted base-promoted (3 + 2) cycloadditions

We have developed unique base-promoted diastereoselective (3 + 2) cycloadditions. A diastereodivergent synthesis of fully disubstituted spiroindoline-3,2′-pyrrolidin-2-ones was realized by tuning a Lewis base/Brønsted base.