OPLAH ablation provides a novel murine model for HFpEF driven by 5-oxoproline-induced oxidative stress, which may help identify novel therapeutic options.
Oxidative stress induced by 5-oxoproline results in a murine phenotype reminiscent of the clinical manifestation of HFpEF without the need for surgical or pharmacological interference. Better understanding of the role of oxidative stress in HFpEF may potentially lead to novel therapeutic options.
Pol et al. (Thu,) studied this question.