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November 1, 2011Open Access

PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent

EGEleni GourniUniversity Hospital of Bern ODOliver DemmerZealand Pharma (Denmark)MSMargret SchotteliusUniversity Hospital of Lausanne

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Resumen

The small and optimized cyclic peptide CPCR4-2 labeled with (68)Ga is a suitable tracer for targeting and imaging of human CXCR4 receptor expression in vivo. The high affinity for CXCR4, its in vivo stability, and the excellent pharmacokinetics recommend the further evaluation of (68)Ga-CPCR4-2 in a proof-of-concept study in humans.

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PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent | Synapse

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Gourni et al. (Tue,) studied this question.

synapsesocial.com/papers/69dae7c1e6ab964fb0836c26 https://doi.org/https://doi.org/10.2967/jnumed.111.098798