Targeted detection of amino acid profiles in pleural fluid and serum by liquid chromatography-tandem mass spectrometry for estimating the risks of four aetiologies of pleural effusion: a proof-of-concept study

Puntos clave

• This study aims to evaluate the feasibility of detecting amino acid profiles in pleural fluid and serum to assess pleural effusion aetiologies.
• Used liquid chromatography-tandem mass spectrometry for amino acid detection.
• Analyzed samples from pleural fluid and serum.
• Explored diagnostic role across four aetiologies of pleural effusion.
• Amino acid detection in pleural effusion and serum is feasible.
• Detection offers a minor to moderate enhancement in diagnostic capability.