RTX-mediated trogocytosis of B cells in vitro results in acute production and release of IL-6. The nature of this effect and how it is related to the acute infusion reactions seen with RTX administration remain to be determined.

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Jones et al. (Wed,) studied this question.

synapsesocial.com/papers/69dbaea450e1971baba3c355 https://doi.org/https://doi.org/10.1002/art.38798

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1Rituximab mediates loss of CD19 on B cells in the absence of cell death2012 · 57 citations
2An Antibody-Deficiency Syndrome Due to Mutations in the<i>CD19</i>Gene2006 · 545 citations
3IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells2003 · 235 citations
4Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab2013 · 111 citations
5Monocytes mediate shaving of B-cell-bound anti-CD20 antibodies2011 · 37 citations

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rituximab mediates loss of CD19 on B cells in the absence of cell death2012 · 57 citations
2An Antibody-Deficiency Syndrome Due to Mutations in the<i>CD19</i>Gene2006 · 545 citations
3IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells2003 · 235 citations
4Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab2013 · 111 citations
5Monocytes mediate shaving of B-cell-bound anti-CD20 antibodies2011 · 37 citations