Flavonoids as Natural Anti-Inflammatory Agents in the Atopic Dermatitis Treatment

Eczema is a complex autoimmune condition characterised mainly by inflammation and skin lesions along with physical and psychological comorbidities. Although there have been significant advances in understanding the mechanisms behind atopic dermatitis, conventionally available treatments yield inconsistent results and have some unintended consequences. In today's digital age, where knowledge is just a click away, natural-based supplements have been on the rise for a more "natural" treatment towards any type of disease. Natural compounds, particularly derived from medicinal plants, have piqued significant interest in the development of herbal remedies for chronic inflammatory skin conditions. Among many compounds, flavonoids have shown promise in treating eczema due to their strong anti-inflammatory, antioxidant, and anti-allergic properties, making them helpful in preventing allergic reactions, inflammation, and skin irritation. This review highlights the therapeutic potential of flavonoid-based bioactive compounds to manage eczema, emphasising the mechanisms of action. Additionally, providing a comprehensive analysis of the potential of emerging and established compounds, while bridging a gap between traditional and modern medicine. Flavonoids offer a variety of opportunities for further research and innovative formulations that can maximise its full benefits. Further combination of flavonoids with various approaches such as nanoencapsulation for enhanced bioavailability, hydrogel-based delivery systems for a controlled release, and additive manufacturing for personalised topical formulations, could align with future precision medicine needs.