Cardiovascular manifestations in pediatric Marfan syndrome progress gradually and can lead to significant morbidity and mortality by late adolescence, particularly in sporadic female cases.
During childhood and adolescence in Marfan syndrome, mitral valve dysfunction as well as aortic abnormalities develop and progress gradually, often without symptoms, but may cause considerable morbidity and mortality by the end of the second decade, especially in female sporadic patients.
Clara van Karnebeek (Thu,) studied this question.
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