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The PTEN/NRF2 Axis Promotes Human Carcinogenesis | Synapse

June 3, 2014Open Access

The PTEN/NRF2 Axis Promotes Human Carcinogenesis

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Resumen

Increased activity of NRF2 due to loss of PTEN is instrumental in human carcinogenesis and represents a novel therapeutic target.

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Cite This Study

Rojo et al. (Tue,) studied this question.

synapsesocial.com/papers/69dcb324c099bcfdbb1332e5 https://doi.org/https://doi.org/10.1089/ars.2014.5843

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.1997 · 701 citations
2SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner2011 · 745 citations
3Toward clinical application of the Keap1–Nrf2 pathway2013 · 675 citations
4Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features2010 · 428 citations
5NRF2 and cancer: the good, the bad and the importance of context2012 · 1,052 citations