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Abstract A chiral lithium amide mediated enantioselective 2,3-Wittig rearrangement of carboxylic acid enolate has been developed. The reaction proceeds through the formation of a chiral mixed aggregate that shields one enantioface of enolate anion to give a highly functionalized chiral α-hydroxycarboxylic acid.
Shirai et al. (Tue,) studied this question.