Pulse nav.journalClub Debates activos Tendencias Explorar Investigadores

Download the App

Join discussions, follow papers, and never miss your next session.

Download on theApp Store

© Synapse Social LLC, 2026

Política de privacidad

Inicio Explorar nav.journalClub Tendencias

⌘+K

Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer | Synapse

March 7, 2016Open Access

Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer

Puntos clave

Los puntos clave no están disponibles para este artículo en este momento.

Resumen

Our data show that a considerable fraction of the aberrant cancer DNA methylation landscape results from a mechanism that is largely tissue specific. Histone marks as specified in the normal cell of origin provide highly predictive models of aberrant cancer DNA methylation and outperform those derived from the same marks in hESCs.

Preguntar a la IA

Me gusta

Guardar

Compartir

Ver artículo completo

Preguntar a la IA

Me gusta

Guardar

Compartir

Ver artículo completo

Cite This Study

Chen et al. (Mon,) studied this question.

synapsesocial.com/papers/69dd4d017d97b7e86940cb8f https://doi.org/https://doi.org/10.1186/s13072-016-0058-4

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Chromatin organization is a major influence on regional mutation rates in human cancer cells2012 · 712 citations
2An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging2015 · 167 citations
3Molecular Rules Governing <i>De Novo</i> Methylation in Cancer2014 · 59 citations
4An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer2009 · 386 citations
5Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer2010 · 892 citations