November 19, 2018Open Access

Fate alteration of bone marrow-derived macrophages ameliorates kidney fibrosis in murine model of unilateral ureteral obstruction

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Our results demonstrate that diversion of β-catenin from TCF to Foxo1-mediated transcription not only inhibits the β-catenin/TCF-mediated fibrotic effect of TGF-β, but also enhances its anti-inflammatory action, allowing therapeutic use of TGF-β to reduce both inflammation and fibrosis at least partially by changing the fate of bone marrow-derived macrophages.

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Yang et al. (Mon,) studied this question.

synapsesocial.com/papers/69dd5c697808b00a4799cfcd https://doi.org/https://doi.org/10.1093/ndt/gfy381

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