Is recent respiratory infection associated with acute myocardial infarction, and does influenza vaccination protect against AMI?
Influenza vaccination may offer protective effectiveness against acute myocardial infarction comparable to standard secondary prevention therapies, highlighting the cardiovascular risk associated with recent respiratory infections.
Our meta-analysis of case-control studies found a significant association between recent respiratory infection and AMI. The estimated vaccine effectiveness against AMI was comparable with the efficacy of currently accepted therapies for secondary prevention of AMI from clinical trial data. A large-scale randomised controlled trial is needed to provide robust evidence of the protective effect of influenza vaccination on AMI, including as primary prevention.
Barnes et al. (Wed,) studied this question.
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