July 5, 2006Open Access

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

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Resumen

Upregulation of pore-forming claudin 2 and downregulation and redistribution of sealing claudins 5 and 8 lead to altered tight junction structure and pronounced barrier dysfunction already in mild to moderately active Crohn's disease.

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Zeißig et al. (Wed,) studied this question.

synapsesocial.com/papers/69de6b6f726bee048db0c06c https://doi.org/https://doi.org/10.1136/gut.2006.094375

Also Consider

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1The JAM family of proteins2005 · 227 citations
2Ultrastructural pathology of Crohn's disease: correlated transmission electron microscopy, scanning electron microscopy, and freeze fracture studies.1983 · 35 citations
3DAPI: a DNA-Specific Fluorescent Probe1995 · 879 citations
4Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor α antibody treatment2004 · 303 citations
5Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis1999 · 604 citations

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