Small Fiber Neuropathy: A Clinical and Practical Approach

Abstract Small fiber neuropathy (SFN) is a peripheral nerve condition causing neuropathic pain and autonomic complaints. Skin biopsy is an important diagnostic tool for diagnosing SFN. SFN is associated with conditions like diabetes mellitus and autoimmune diseases, but in 53% of the patients, the etiology remains unknown. Treating the underlying condition is the first-line treatment, but most patients will also need symptomatic treatment based on the biopsychosocial model. SFN can be managed by several health care professionals, including nurse practitioners, neurologists, pain specialists, and physiatrists. This article provides evidence-based information on the diagnostics of SFN and offers guidance for interdisciplinary treatment.