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It′s a rate thing: Crucial conceptual advances have allowed for the development of a Pd-mediated pathway to CarylF by using either electrophilic (right) or nucleophilic (left) fluorinating reagents. Of significance is the recognition that PdIV intermediates reduce the barrier to CF reductive elimination and the use of an ancillary bulky ligand to force reductive elimination from a 14-electron PdII complex.
Brown et al. (Tue,) studied this question.
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