December 1, 1999

Proinflammatory Mediators Stimulate Neutrophil-Directed Angiogenesis

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Resumen

Activated human PMNs are directly angiogenic by releasing VEGF, and this has important implications for inflammation, capillary leak syndrome, wound healing, and tumor growth.

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Cite This Study

Morgan McCourt (Wed,) studied this question.

synapsesocial.com/papers/69de9730499d77a496b0bf5f https://doi.org/https://doi.org/10.1001/archsurg.134.12.1325

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Vascular permeability factor (VPF, VEGF) in tumor biology1993 · 846 citations
2Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.1987 · 712 citations
3Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response1995 · 190 citations
4ACTIVATED HUMAN NEUTROPHILS EXPRESS VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)1998 · 146 citations
5Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA1973 · 6,896 citations

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