Interaction of Onset and Duration of Diabetes on the Percent of GAD and IA-2 Antibody–Positive Subjects in the Type 1 Diabetes Genetics Consortium Database

Onset and duration of diabetes both have an important effect on antibody status. The interaction of onset and duration on GADA positivity, but not on IA-2A, suggests differences in biology. These data provide a context for clinicians to interpret results of autoantibody testing in clinical practice.