December 17, 2016Open Access

Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells

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We have identified that PHB1, down-regulated in most human HCC and CCA, heterodimerizes with MAX to repress the E-box and positively regulates MAT1A while suppressing c-MYC, MAFG, and c-MAF expression; in mice, reduced PHB1 expression predisposes to the development of cholestasis-induced CCA. (Hepatology 2017;65:1249-1266).

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Fan et al. (Sat,) studied this question.

synapsesocial.com/papers/69de9d80210a0977fce94eb6 https://doi.org/https://doi.org/10.1002/hep.28964

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