Classification of PPMI MRI scans with voxel-based morphometry and machine learning to assist in the diagnosis of Parkinson’s disease

The proposed method provides high performance as an assisting tool in the diagnosis of Parkinson's disease, by conducting separate experiments in men and women. While previous works have focused their analysis to the striatum region of the brain (the largest nuclear complex of the basal ganglia), the proposed approach is based on analysis over the whole brain by looking for decreases of tissue thickness, with the consequence of finding other regions of interest such as the cortex.