What question did this study set out to answer?

This study aims to analyze the differences in primary endpoints and definitions of outcomes in acute stroke trials using the Barthel Index and Modified Rankin Scale.

August 1, 1999Open Access

Use of the Barthel Index and Modified Rankin Scale in Acute Stroke Trials

Puntos clave

This study aims to analyze the differences in primary endpoints and definitions of outcomes in acute stroke trials using the Barthel Index and Modified Rankin Scale.
Analysis of efficacy trials focusing on acute stroke outcomes.
Comparison of definitions for favorable and poor outcomes based on Barthel Index and Modified Rankin Scale.
Identified significant variations in the choice of primary endpoints across trials.
Highlighted difficulties in defining favorable outcomes, suggesting poor outcome definitions are clearer.

Resumen

Among the efficacy trials in acute stroke, we found remarkable differences in the choice of primary end points and in the definition of favorable outcome on both the BI and MRS. This lack of consensus strongly hinders the design, interpretation, and comparison of acute stroke trials. In general, it may be easier to define poor outcome instead of favorable outcome. Poor outcome could be defined if any of the following end points are reached: death, institutionalization due to stroke, MRS >3, or BI <60.

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