October 21, 2014Open Access

Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

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Resumen

Disruption of Drp1 induces mitochondrial elongation, inhibits mitochondrial autophagy, and causes mitochondrial dysfunction, thereby promoting cardiac dysfunction and increased susceptibility to ischemia/reperfusion.

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Ikeda et al. (Tue,) studied this question.

synapsesocial.com/papers/69df142ad9e0feb21c591723 https://doi.org/https://doi.org/10.1161/circresaha.116.303356

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5Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes2011 · 392 citations

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