March 6, 2019

A New Class of Medicines through DNA Editing

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Resumen

Interview with Dr. Matthew H. Porteus on therapeutic editing of the human genome. (12:58)Download Therapeutic editing of the human genome has long been a holy grail of genetic medicine. Different approaches are founded on a bedrock of basic laboratory discovery. This article describes the history, applications, and limitations of genome editing for clinical application.

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Cite This Study

Matthew H. Porteus (Wed,) studied this question.

synapsesocial.com/papers/69df3064d9e0feb21c592134 https://doi.org/https://doi.org/10.1056/nejmra1800729

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing2018 · 67 citations
2TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy2014 · 126 citations
3CRISPR/Cas9 genome editing in human hematopoietic stem cells2018 · 327 citations
4Gene targeting using zinc finger nucleases2005 · 640 citations
5Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors2015 · 265 citations

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