Impact of altered loading conditions on ventricular performance in fetuses with congenital cystic adenomatoid malformation and twin–twin transfusion syndrome

In both CCAM and recipient twins of the TTTS, diastolic dysfunction plays a significant role in the pathophysiology of each disorder and precedes changes in systolic performance. Measures of ventricular performance can help elucidate poorly understood mechanisms of cardiovascular compromise in the developing fetus.