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Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity | Synapse

September 19, 2011Open Access

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Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity

HNHong‐Min NiUniversity of Kansas Medical Center ABAbigail Bockus NBNikki BoggessUniversity of Kansas Medical Center

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Resumen

APAP overdose induces autophagy, which attenuates APAP-induced liver cell death by removing damaged mitochondria.

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Cite This Study

Ni et al. (Mon,) studied this question.

synapsesocial.com/papers/69df6e0135659245ec614e5b https://doi.org/https://doi.org/10.1002/hep.24690

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1Is mitochondrial generation of reactive oxygen species a trigger for autophagy?2008 · 235 citations
2Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes2004 · 118 citations
3Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice1988 · 211 citations
4Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.1985 · 169 citations
5Autophagy as a Regulated Pathway of Cellular Degradation2000 · 3,606 citations