A Dendritic Thioester Hydrogel Based on Thiol–Thioester Exchange as a Dissolvable Sealant System for Wound Closure

Washable wound dressing: A dissolvable dendritic thioester hydrogel for wound closure has been developed. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. This material can be washed off upon exposure to thiolates because a thiol–thioester exchange takes place, and gradual wound re-exposure may be achieved during surgical care.