Measurement and Correlation of Solubility of Olmesartan Medoxomil in Six Green Solvents at 295.15–330.15 K

The aim of present study was to measure and correlate the mole fraction solubility of olmesartan medoxomil (OLM) in six green solvents, namely, water, ethanol, propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethylene glycol (EG), and Transcutol from (295.15 to 330.15) K at atmospheric pressure using the shake flask method. The experimental solubilities of OLM were correlated with the Apelblat equation. The root-mean-square deviations between experimental and calculated solubility were observed in the range of 3.360 × 10–8 to 0.013 × 10–3 in all green solvents. However, the correlation coefficients in water, ethanol, PG, PEG-400, EG, and Transcutol were observed in the range of 0.996–0.998, indicating a good fit. The solubility of OLM was found to be higher in PEG-400 (2.58 × 10–3 at 298.15 K) and Transcutol (2.48 × 10–3 at 298.15 K) as compared to water (2.32 × 10–7 at 298.15 K), ethanol (4.67 × 10–4 at 298.15 K), PG (9.23 × 10–5 at 298.15 K) and EG (6.73 × 10–5 at 298.15 K).