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Gene‐dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis | Synapse

July 14, 2022Open Access

Gene‐dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis

SGShuai GuoHebei University ALAnqi LiShanghai University XFXiaodong FuSun Yat-sen University

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Resumen

Collectively, these findings suggest the existence of a double-edged sword effect of myeloid PFKFB3 on the pathogenesis of atherosclerosis and highlight the need for caution in developing anti-atherosclerotic strategies that target PFKFB3.

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Cite This Study

Guo et al. (Thu,) studied this question.

synapsesocial.com/papers/69e005cb1827a1d0b1255e4e https://doi.org/https://doi.org/10.1111/bph.15926

Also Consider

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1Role of PFKFB3-Driven Glycolysis in Vessel Sprouting2013 · 1,586 citations
2Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques2007 · 1,309 citations
3Phagocytosis of Apoptotic Cells by Macrophages Is Impaired in Atherosclerosis2005 · 512 citations
4PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense2016 · 122 citations
5HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages2015 · 188 citations